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procedure for the conversion of an anti-inflammatory active steroids, which crystal growth in aerosol propellants, a form which does not exhibit such crystal growth.
procedure for the conversion of an anti-inflammatory active steroids, which crystal growth in aerosol propellants, a form which does not exhibit such crystal growth.
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机译:消炎活性类固醇的转化方法,该类固醇在气溶胶推进剂中晶体生长,这种形式不表现出这种晶体生长。
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摘要
An antiinflammatory steroid exhibiting a tendency to crystal growth in suspension in aerosol propellants is contacted with a halogenated hydrocarbon to form a crystalline solvate, which, after removal of some or all of the propellant from the crystals, is reduced to a particle size permitting inhalation into the human bronchial system when dispersed as an aerosol, the micronised crystalline solvate not thereafter exhibiting crystal growth in the aerosol propellant. The solvate is a new composition of matter which has been characterized by I.R. spectra and the aerosol formulation prepared therefrom has valuable therapeutic properties, particularly in the treatment of asthma.
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