PHARMACEUTICAL FORMULATIONS COMPRISING MICROENCAPSULATED AMPICILLIN TRIHYDRATE OR AMOXYCILLIN TRIHYDRATE
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机译:包含微胶囊化的氨苄西林三水合物或阿莫西林三水合物的药物制剂
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1403584 Encapsulated antibiotics BEECHAM GROUP LTD 16 May 1973 [19 May 1972] 23576/72 Heading A5B A powder useful in the formulation of pharmaceutical preparations consists essentially of "microcapsules" having an average diameter of 100Á to 300u, at least 90% of the microcapsules having diameters in the range 75u to 450Á and which comprises 98% to 99.9% of a #-lactam antibiotic coated by 0.17 to 2% of polyvinylpyrrolidone. The term "microcapsule" means a particle composed of an outer, generally porous shell of PVP as coating agent with an inner core of fine particles. They may be made by spray-drying a slurry of antibiotic in a solution of PVP in a suitable solvent. Many conventional solid and liquid formulations comprising the microcapsules are mentioned. Specified antibiotics include; ampicillin, amoxicillin, isoxazolylpenicillin, salts and esters thereof and esters of ampicillin and carbenicillin.
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机译:1403584封装的抗生素BEECHAM GROUP LTD 1973年5月16日[1972年5月19日] 23576/72标题A5B用于制备药物制剂的粉末主要由平均直径为100µ至300u的“微胶囊”组成,至少占微胶囊的90%直径在75u至450µ范围内,并包含98%至99.9%的#-内酰胺抗生素,并被0.17%至2%的聚乙烯吡咯烷酮包覆。术语“微胶囊”是指由PVP的外部,通常为多孔的壳作为包衣剂和细颗粒的内芯组成的颗粒。它们可以通过将抗生素的浆液在合适的溶剂中的PVP溶液中喷雾干燥而制成。提及了许多包含微胶囊的常规固体和液体制剂。指定的抗生素包括;氨苄青霉素,阿莫西林,异恶唑基青霉素,其盐和酯以及氨苄青霉素和羧苄青霉素的酯。
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