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still for framstellning of prostaglandins of the pge type? 712 with foreningar type pga? as utgangsforeningar
still for framstellning of prostaglandins of the pge type? 712 with foreningar type pga? as utgangsforeningar
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机译:还在生产pge型前列腺素吗? 712,关联类型为pga?作为出口协会
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摘要
Process comprises (1) oxidising 15 beta-PGA2 acetate methyl ester to corresp. alpha and beta 10,11 epoxide, (2) reducing the epoxides to a mixture of 15 beta-PGE2 and 11 beta, 15 beta-PGE2 15-acetate methyl esters, (3) separating the latter, (4) silylating the 15 beta-PGE2 15-acetate methyl ester to 15 beta-PGE2 11-O-Si-(CH3)3 ether 15-acetate methyl ester, (5) reducing the product from 4 and then hydrolysing to give the 15 beta PGF2 alpha and 15 beta-PGF2 beta-15 acetate methyl ester, (6) separating the mixture, (7) saponifying the 15 beta-PGF2 alpha 15-acetate methyl ester to 15 beta-PGF2 alpha, (8) oxidising the latter to 15-oxo-PGF2 alpha, (9) silylating the latter to 15-oxo-PGF2 alpha 9,11-Di-Si-(CH3)3 ether or the corresp. -Si(CH3)3 ester, (10) reducing the product from 9 and then hydrolysing to give PGF2 alpha/15 beta-PGF2 alpha which mixture is separated.
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