A procedure for the preparation of derivatives of 1-amino- (replaced) -3-4'-0-5'-tiazol (replaced) -2-oxi-2-propanol. (Machine-translation by Google Translate, not legally binding)

摘要

A process for the preparation of 1-amino (substituted) -3- (4'- or 5'-thiazole (substituted) -2-oxy) -2-propanol derivatives of the formula: **(See formula)** where 2 is a substituent on the thiazole ring at any one of positions 4 or 5, selected from the group of formulas: **(See formula)** where one of the radicals R3 or R4 is independently selected from alkyl of 7 to 12 carbon atoms; cycloalkyl of 3 to 12 carbon atoms; a terminally substituted alkyl group of 2 to 12 carbon atoms, with a substituted terminal carbon atom bearing one to three substituents independently selected from the group consisting of hydroxy, acyloxy of 2 to 12 carbon atoms, and alkoxy of 1 to 6 carbon atoms; and formula groups **(See formula)** where n is an integer from 1 to 4, R8 and R9 are independently selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R10 is cycloalkyl of 3 to 8 carbon atoms; and the other of the radicals R3 or R4 is selected from hydrogen; alkyl of 1 to 12 carbon atoms; cycloalkyl of 3 to 12 carbon atoms; phenyl, lower phenylalkyl where the alkyl radical contains from 1 to 6 carbon atoms, substituted phenyl and substituted lower phenylalkyl where said phenyl ring carries one or two substituents independently selected from the group consisting of hydroxy, lower alkyl, lower alkoxy and halogen; a terminally substituted alkyl group of 2 to 12 carbon atoms, with a substituted terminal carbon atom bearing 1 to 3 substituents independently selected from the group consisting of hydroxy, acyloxy of 2 to 12 carbon atoms, and alkoxy of 1 to 6 carbon atoms; and formula groups **(See formula)** where n is an integer from 1 to 4 and R8 and R9 are independently selected from hydrogen and alkyl groups of 1 to 4 carbon atoms and R10 is cycloalkyl of 3 to 8 carbon atoms; R7 is hydrogen, lower alkyl, aryl, or arylalkyl; and also with the condition that when Z is (see formula), then R4 cannot be hydrogen; whose procedure consists of hydrolyzing the corresponding compounds of formula: **(See formula)** where Z and R7 are those defined above, under acidic or basic conditions, thereby forming the corresponding compound of formula Ia. (Machine-translation by Google Translate, not legally binding)