The method of obtaining derivatives of biphenyl or their salts, or racemates, or optically active antipodes

摘要

1411495 3 - (Fluoro - 4 - biphenylyl) - 3- hydroxy - butyric acids and derivatives thereof DR KARL THOMAE GmbH 16 Aug 1973 [17 Aug 1972] 38843/73 Heading C2C The invention comprises compounds of the formula wherein R 1 is F in the 21- or 4SP1/SP-position, B is OH, alkoxy or a group in which R 2 and R 3 are H, -CH 2 COOH, (C 1 -C 5 )alkyl or phenyl optionally substituted by OH or CH 3 , and where B is OH, the salts of thereof with inorganic or organic bases. Compounds in which B is alkoxy may be obtained by reacting a compound of the formula with the Zn compound of an appropriate haloacetate ester in the presence of an organic solvent. Compounds in which B is OH and salts thereof may be obtained by saponification of compounds of Formula I in which B is alkoxy with an alkali or a strong acid and liberating the free acids from salts thereof by acidification with a mineral acid. Compounds in which B is may be obtained by reacting compounds of Formula I in which B is alkoxy or compounds in which said alkoxy group is replaced by a halogen atom, with an amine of the formula Examples are given for the production of the compounds. The compounds of Formula I have antiphlogistic activity and may be administered orally, rectally or parenterally in conventional forms.