Basic substituted 1,4 - benzo dioxanes and their pharmacologically not toxic acid-addition salts and method for their preparation and pharmaceutical compositions containing these compounds

摘要

1388325 Derivatives of benzo-1,4-dioxan MANUFACTURE DE PRODUITS PHARMACEUTIQUES A CHRISTIAENS SA 25 Sept 1973 [26 Sept 1972] 44435/72 Heading C2C The invention comprises compounds of formula and their acid addition salts, wherein n= 1 or 2, X is O: or H 2 , A is Ph or 2-pyridyl, and either R 1 is C 1-4 alkyl and R 2 is H or C 1-4 alkyl, or NR 1 R 2 forms a heterocyclic ring. In examples, these compounds are prepared (where Z is benzo-1,4-dioxan-2-yl) by (a) reacting the chloroalkyl compound with HNR 1 R 2 ; (b) reacting the arylaminomethyl compound ZCH 2 NHA (made from the sulphonate ZCH 2 O 3 SMe and ANH 2 ) with or (c) reducing the amides (X=O:) to the amines (X=H 2 ). Therapeutic compositions for oral or parenteral administration comprise compounds of the above formula, which have antiarrhythmic activity and are not depressants for the myocardial function.