N-(trifluoromethyl benzyl) phthalimides - intermediates for biologically active trifluoromethyl benzylamines

摘要

New N-(trifluoromethyl-benzyl)phthalimides are of formula (I) (where R1 is H, halogen, OCF3, alkyl, alkoxy, alkylamino or dialkylamino). (I) can be hydrolysed or hydrazinolysed to the corresp. trifluoromethylbenzylamines (II) which have biological activity. A typical cpd. is N-(3-trifluoromethylbenzyl) phthalimide This is prepd. in 72% by e.g. reacting N-hydroxymethyl-phthalimide with benzotrifluoride in H2SO4.