IMDAZOBENSODIAZEPINES

摘要

This invention relates to 1H-imidazo[1,2-a][1,4]-benzodiazepine-1,2(3H)-diones of the formula WHEREIN R is selected from the group consisting of hydrogen, lower alkyl of 1 through 4 carbon atoms and lower alkenyl of 3 through 4 carbon atoms; R1 is selected from the group consisting of hydrogen and lower alkyl of 1 through 3 carbon atoms; R2 is selected from the group consisting of 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, furyl, pyrryl, thienyl, lower alkyl of 1 through 3 carbon atoms, lower alkenyl of 2 through 4 carbon atoms, cycloalkyl of 5 through 7 carbon atoms, cycloalkenyl of 5 through 7 carbon atoms and WHEREIN R5 and R6 are selected from the group consisting of hydrogen, lower alkyl of 1 through 3 carbon atoms, halogen, nitro, cyano, trifluoromethyl, lower alkoxy of 1 through 3 carbon atoms, lower alkylthio of 1 through 3 carbon atoms, lower alkylsulfinyl of 1 through 3 carbon atoms, lower alkylsulfonyl of 1 through 3 carbon atoms, lower alkanoylamino having lower alkyl moieties of 1 through 3 carbon atoms and lower dialkylamino having lower alkyl moieties of 1 through 3 carbon atoms; R3 and R4 have the same meaning as R5 and R6, above; and a pharmacologically acceptable acid addition salt thereof. The new products of Formula 1 are useful as sedatives, hypnotics, tranquilizers, muscle relaxants and anti-convulsants in mammals and birds.