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PHENYL ACETIC ACID DERIVATIVES PROCESS FOR THEIR PREPARATION AND APPLICATIONS THEREOF POLYESTER CATALYSTS
PHENYL ACETIC ACID DERIVATIVES PROCESS FOR THEIR PREPARATION AND APPLICATIONS THEREOF POLYESTER CATALYSTS
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机译:苯乙酸衍生物的制备及其在聚酯催化剂中的应用
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1421971 Benzofuran derivatives SERDEXSOC D'ETUDES DE RECHERCHES DE DIFFUSION ET D'EXPLOITATION 13 June 1974 [26 June 1973] 30196/73 Heading C2C Novel compounds I (in which R 1 =H or C 1-6 alkyl, R 2 =H, halogen, C 1-6 alkoxy or C 1-6 alkyl, R 3 =H, C 1-6 alkyl or aryl, and R 4 =H, halogen, CF 3 , OH, C 1-6 alkyl or C 1-6 alkoxy) and pharmalogically acceptable salts and esters thereof, are preprepared by reacting a compound II with a compound III in which R=C 1-6 alkyl and X=halogen, and saponifying the resulting ester to give the corresponding acid. Compounds III are obtained by halogenation of acetyl - phenyl - acetic acid derivatives IV: which are themselves prepared by a Friedel- Crafts reaction between the corresponding phenyl-acetic acid derivatives and acetyl chloride. Pharmaceutical compositions having analgesic and anti-inflammatory activity, for oral or rectal administration, comprise one of the above novel compounds together with a pharmaceutical carrier.
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