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Normolipaemic and hypocholesterolaemic agent prepn. - by reacting salt of 4-chlorophenoxy-isobutyric acid with 1-halo-2,3-dinicotinoyloxy-propane
Normolipaemic and hypocholesterolaemic agent prepn. - by reacting salt of 4-chlorophenoxy-isobutyric acid with 1-halo-2,3-dinicotinoyloxy-propane
1-(4-Chlorophenoxyisobutysyloxy)-2,3-dinicotinoyl-oxy-propane (I) is prepd. by esterifying a metal deriv. of formula (II) in dimethylformamide or formamide, with a halopropane of formula (III) (where M is alkali(ne earth) metal; n is a number which, when multiplied by the valency of M is 1; X is halogen). (I) has normolipaemic and hypocholesterolaemic activity used in human and veterinary medicine. High yields are obtd.
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