(2)-Dicyclohexyl-ethyl yrrolidines - with coronary vasodilator and spasmolytic activity

摘要

New 2-(2,2-dicyclohexylethyl)pyrrolidines are of formula (where R is H or 1-4C alkyl). A typical cpd. 2-(2,2-di-cyclohexylethyl)pyrrolidine, is prepd. by reaction of phenyl-magnesium bromide with ethyl pyrrolidin-2-ylacetate to give 1,1-diphenyl-2-(2-pyrrolidiny)ethanol which is dehydrated to give 2-(2,2-diphenylvinyl)pyrrolidine which is then hydrogenated.