Process for making 2,6-difluoropyridine

摘要

It has been found that practical reaction rates can be attained without resort to the high temperatures previously employed in the preparation of 2,6-difluoropyridine from the corresponding dichloropyridine and KF, if:PPA. dimethyl sulfoxide is employed as the reaction medium;PPB. the reaction mixture contains solid KF particles and dissolved tetramethyl ammonium or phosphonium chloride;P PC. there is present in the reaction mixture less than 0.1 grams of acids, bases or organic hydroxy compounds and less than 1.0 grams of water, per 100 grams of solvent, andPPD. the reaction mixture is intensely stirred.