Pharmaceutical aryl-pyridazinyl-hydrazine salt - specifically racemic 3-(2-(3-tert.-butylamino-2-hydroxypropoxy) phenyl)-6-hydrazine-pyridazine-D-hydrochloride mono:hydrate

摘要

Racemic 3- 2-(3-t-butylamino-2-hydroxypropoxy)phenyl -6-hydrazinopyridazi- ne dihydrochloride monohydrate of formula (I) is new: USE/ADVANTAGE : USES/ADVANTAGES (I) has beta-adrenergic blocking and vasodilatory activity (see also BE 830158). Unlike other salts (e.g. the hemisulphate hemihydrate), (I) is a stable non-hygroscopic solid which can be tabletted readily and prepd. with a reproducible H2O content. It is less liable to cause diarrhoea than the hemisulphate hemihydrate.