首页> 外国专利> still for framstellning of d, 1 - cis - 1 - hydroxy - 3 - substituted - 2.6 - dimethyl - 6,6alfa, 7,8,10,10alfa - hexahydro-1,3,5-trinitro-1,3,5-triazine - 9h dibenzo (b, d) pyran - 9 - regions

still for framstellning of d, 1 - cis - 1 - hydroxy - 3 - substituted - 2.6 - dimethyl - 6,6alfa, 7,8,10,10alfa - hexahydro-1,3,5-trinitro-1,3,5-triazine - 9h dibenzo (b, d) pyran - 9 - regions

机译:仍用于d,1-顺式-1-羟基-3-取代-2.6-二甲基-6,6alfa,7,8,10,10alfa-六氢-1,3,5-三硝基-1,3,5-三嗪-9h二苯并(b,d)吡喃-9-地区

摘要

dl-6a,10a-cis-1-Hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a- hexahydro-9H-dibenzo[b,d]pyran-9-ones of the formula IMAGE in which R represents C5-C10-alkyl, C5-C10-alkenyl, C5-C8-cycloalkyl or C5-C8-cycloalkenyl, where the hydrogen atoms present in the positions 6a and 10a are arranged in the cis-position to one another. These compounds are obtained by reacting a 1-alkoxy-4-(1-hydroxy-1-methylethyl)-1,4-cyclohexadiene with a resorcinol containing the radical R in the 5-position in the presence of a catalyst from the group consisting of boron tribromide, boron trifluoride, or tin(IV) chloride in an inert organic solvent. The compounds obtained can be used as medicaments for the treatment of anxiety states and depressions.
机译:dl-6a,10a-顺式-1-羟基-3-取代的6,6-二甲基-6,6a,7,8,10,10a-六氢-9H-二苯并[b,d]吡喃-9-式,其中R代表C5-C10-烷基,C5-C10-烯基,C5-C8-环烷基或C5-C8-环烯基,其中在位置6a和10a中存在的氢原子排列在顺式-彼此定位。这些化合物是通过使1-烷氧基-4-(1-羟基-1-甲基乙基)-1,4-环己二烯与在5位上含有R基团的间苯二酚在存在催化剂的情况下反应而制得的在惰性有机溶剂中加入三溴化硼,三氟化硼或氯化锡(IV)。所获得的化合物可以用作治疗焦虑症和抑郁症的药物。

著录项

  • 公开/公告号SE7707631L

    专利类型

  • 公开/公告日1978-01-07

    原文格式PDF

  • 申请/专利权人 LILLY CO ELI;

    申请/专利号SE19770007631

  • 发明设计人 LAVAGNINO E R;DAY W A;RYAN C W;

    申请日1977-06-30

  • 分类号C07D311/80;

  • 国家 SE

  • 入库时间 2022-08-22 22:36:59

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