disackaridderivat of anthracyclines and still for framstellning derav

摘要

Anthraqcydin derivs. of formula (I) and their salts are new. In (I) either (a) R'=R3=R5=H; R2=NH2; R4=OH; (b) R=R3=R4=R5=H; R2=NH2; (c) R'=R4=R5=H; R3=OG; (d) R'=NH2; R2=R4=R5=H; R3=OG; (e) R==R4=R5=H; R2=R3=OH; (f) R'=R3=OH; R2=R4=R5=H; R2=R4;R5=H; or (g) R'=R3=R5=H; R2=R4=OH. (I) can be prepd. by reacting N-trifluoroacetyldaunomycin with a protected 1-halo-sugar in the presence of a soluble silver salt as catalyst and then the protecting gps. by mild alkaline hydrolysis. (I) have an antineoplastic effect. they can be used to treat malign neoplasia.