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SEEN TO PROMOTE THERAPEUTICAL VERIFICATION OF NEW 2-METYL-2-FENOXI PROPION ACIDATES

机译:有望促进新型2-甲基-2-戊酸丙酸酯的治疗性验证

摘要

This invention relates to compounds having the formula: IMAGE (I) which represents the isomer Z, the isomer E or the mixture of both stereoisomers of the oximino group and in which: A represents O or S, X1 represents a halogen atom, a hydrogen atom or a methyl group, R represents a hydrogen atom or a C1-5 alkyl group, X2 and X3, which may be the same or different, represent each a hydrogen atom, a halogen atom or a C1-5 alkyl group, and R' represents a hydrogen atom or a C1-5 alkyl group, and the group IMAGE is at 2- or 3-position on the heterocycle, and the salts of acids of the formula (I) with physiologically acceptable bases, and the compounds which are metabolically converted to compounds of the formula (I). Said compounds are therapeutically useful, typically as hypocholesterolemic, hypolipemic and uricosuric agents.
机译:本发明涉及具有下式的化合物:式(I)代表异构体Z,异构体E或肟基的两种立体异构体的混合物,其中:A代表O或S,X1代表卤原子,氢原子或甲基,R表示氢原子或C 1-5烷基,X 2和X 3可以相同或不同,分别表示氢原子,卤素原子或C 1-5烷基, R'代表氢原子或C1-5烷基,基团在杂环的2-或3-位,以及式(I)的酸与生理上可接受的碱的盐,和通过代谢转化为式(I)化合物的化合物。所述化合物在治疗上有用,通常作为降血脂药,降血脂药和尿酸尿酸药。

著录项

  • 公开/公告号SE7801646L

    专利类型

  • 公开/公告日1978-08-14

    原文格式PDF

  • 申请/专利权人 ALBERT * ROLLAND SA;

    申请/专利号SE19780001646

  • 发明设计人 J * LAFOREST;J * BONNET;P * BESSIN;

    申请日1978-02-13

  • 分类号C07D307/52;C07D333/22;

  • 国家 SE

  • 入库时间 2022-08-22 22:35:40

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