NOVEL CORTICOID * PREPARATION THEREOF AND ANTIIINFLAMATORY PHARMACEUTICAL AGENT CONTAINING THE SAME

摘要

New 6alpha, 9alpha-difluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien- e-3,20-dione esters are cpds. of formula (I) in which n is 2 or 3. In an example, ((I) n=2) is prepd. by refluxing 6alpha,-9alpha-difluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pr- egnadiene-3,20-dione (difluocortolone) 5 mins. with butyric anhydride in the presence of pyridine. In a second example, (I) n = 3) is prepd. by refluxing difluorocortolone 5 mins. with valeric anhydride in the presence of pyridine. (I) are corticoids with significantly stronger anti-inflammatory activity than the parent free alcohol (difluocortolone) and its acetate (DT 1211194) and hexanoate (DT 1493178).