procedure for determination of normal and pathological plasma lipoproteins in human body fluids and apparatus for carrying out the process

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• 3. procedure for determination of normal and pathological plasma lipoproteins in human body fluids and apparatus for carrying out the process [P] . AT320865B . 1975-03-10

  机译： 人体液体中正常和病理性血浆脂蛋白的测定方法以及进行该方法的设备

• 4. procedure for determination of normal and pathological plasma lipoproteins in human body fluids and apparatus for carrying out the process [P] . 法国专利： FR2217692A1 . 1974-09-06

  机译： 人体液体中正常和病理性血浆脂蛋白的测定方法以及进行该方法的设备

• 5. procedure for determination of normal and pathological plasma lipproteinmustern in human koerperfluessigkeiten and apparatus for carrying out the process [P] . 德国专利： DE000002314964A . 1974-09-05

  机译： 人koerperfluessigkeiten中正常和病理性血浆脂蛋白异常的测定方法以及进行该方法的装置

• 1. Manifestation of Pathological States of Numerous Diseases in the Largest Organ of the Human Body: (II) From Pancreatitis to Pancreatic Cancer Invasion, Formation of Stroma around the Primary Tumor in the Fascia, to Early Detection of Non-Coding microRNAs in Body Fluids and Development of Drugs to Treat Different Stages of Pancreatic Cancer [J] . Peter Chin Wan Fung, Regina Kit Chee Kong 临床医学国际期刊（英文） . 2020,第010期
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• 1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 2. Intravascular infusion of autologous delipidated plasma induces antiatherogenic lipoproteins and causes regression of atherosclerosis br—Studies in non-primates, monkeys and humans [J] . Bill E. Cham ,Tania R. Chase . 健康（英文） . 2013,第7期
• 3. 坚持设备管理与设备保养及维修管理是企业生产正常进行的保证 [C] . 谢忠英 . 2005全国医药行业现代设备管理及新技术应用研讨会 . 2005
• 4. 人体正常皮肤及病理性瘢痕中神经生长因子及其前体的表达 [A] . 周一冲 . 2014