Derivs. of formula (I): (where one of R1 and R2 is H or lower alkyl and the other is NO2; R3 is lower alkyl, hydroxyalkyl, alkoxyalkyl, alkyl-sulphonyl-alkyl or aminoalkyl; R4 is O or S; X is CO and R5 is lower alkoxy, NH2 or mono- or di(lower alkyl)-amino or X is CS, SO or SO2 and R5 is lower alkyl, aryl, NH2 or mono- or di-(lower alkyl)-amino; and "alk" is lower alkylene with 2-4 C-atoms in the alkylene chain) (e. g. 1-(methyl-thiocarbamoyl)-2-oxo-3-(1-methyl-5-nitro-2-imidazolyl)-- tetrahydroimidazole) and their salts and N-oxides are new cpds. They may be prepd. e.g. by reacting a cpd. of formula (II) (where Z is a reactive esterified or etherified hydroxy gp., a free or etherified mercapto group, an ammonium gp. or a sulphonyl gp.) with a cpd. of formula (III). (I) are antimicrobial and anthelmintic agents active against bacteria (esp. gram-negative bacteria), protozoa and worms such as trichomonads, schistosomes, coccidia and, especially, amoebae. (I) may thus be used for therapeutic purposes, as animal feed additives, and for protecting organic materials against microbial degradation.
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机译:派生。式(I)的通式:(其中R 1和R 2之一为H或低级烷基,另一个为NO 2; R 3为低级烷基,羟烷基,烷氧基烷基,烷基-磺酰基烷基或氨基烷基; R 4为O或S; X为CO R5为低级烷氧基,NH2或单或二(低级烷基)-氨基或X为CS,SO或SO2,R5为低级烷基,芳基,NH2或单或二(低级烷基)-氨基;和“ alk”是在亚烷基链中具有2-4个C原子的低级亚烷基)(例如1-(甲基-硫代氨基甲酰基)-2-氧代-3-(1-甲基-5-硝基-2-咪唑基)-四氢咪唑)它们的盐和N-氧化物是新的cpds。他们可能是准备。例如通过反应一个cpd。式(II)的化合物(其中Z为反应性酯化或醚化的羟基基团,游离或醚化的巯基基团,铵基或磺酰基基团)具有cpd。式(III)的通式。 (I)是对细菌(特别是革兰氏阴性细菌),原生动物和蠕虫如滴虫,血吸虫,球虫,尤其是变形虫具有活性的抗菌剂和驱虫剂。 (I)因此可以用作治疗目的,用作动物饲料添加剂,并用于保护有机材料免于微生物降解。
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