首页>
外国专利>
Hydroxy-indanyl-propylamine prepn. - using (2)-indanone-cyanhydrin with hydroxyl group protected by reaction with vinyl alkyl ether
Hydroxy-indanyl-propylamine prepn. - using (2)-indanone-cyanhydrin with hydroxyl group protected by reaction with vinyl alkyl ether
展开▼
机译:羟基茚满基丙胺制备。 -使用具有通过与乙烯基烷基醚反应保护的羟基的(2)-茚满酮-氰醇
展开▼
页面导航
摘要
著录项
相似文献
摘要
1-(2-Hydroxy-2-indanyl)propylamine is prepd. from 2-indanone cyanhydrin in which the hydroxyl group is protected by a vinyl alkyl ether group of formula RO.CH:CH2 (where R is 1-6C alkyl), by addition of an ethylmagnesium halide hydrolysing the reaction product and hydrogenating the imine to an amine group and removing the protective group. The product, an anorectic and lipolytic agent, is made in 55-60% yield without any increase in cost of raw materials. Typically, the cyanhydrin is protected by reaction with vinyl ethyl ether in THF, the solvent is evapd. and the residue in toluene is treated with ethylmagnesium bromide in THF, and the product hydrolysed. The imine in toluene is hydrolysed with LiAlH4 and converted into the hydrochloride (yield 57% of overall).
展开▼