Coronary vasodilator controlled release dipyridamole compsn. - comprises film coated granules giving reduced side effects and also showing angina pectoris suppressing action

摘要

coronary vasodilator compsn. comprising granules, not more than 2mm. in dia. of dipyridamole enclosed in a film, insoluble or only slightly soluble in water at 37 degrees C, which swells in contact with water and is degradable by man. The compsn. shows reduced side-effects such as headache, intestinal disorders and dizziness and also suppresses angina pectoris. Pref. film thickness is 0.1-200 mu m. When the interior of the granule comprises dipyridamol alone, it is to a concn. of 60-95%. It is pref. deposited on a biodegradable carrier such as starch, protein and esp. paraffins and stearin. Suitable film-formers are gelatin, ethylcellulose, polyvinyl alcohols, polyvinylpyrrolidone, polyamides etc. Pref. release time of the dipyridamol is 4-8 hr.