PERFECTED PROCESS FOR PRODUCING SPONGIOUS COLLAGEN, AND ITS APPLICATION AS AN INTRA-VAGINAL CONTRACEPTIVE DEVICE AND FOR THE RELEASE OF AN ACTIVE PRINCIPLE

摘要

The invention describes the regeneration of collagen and the production of a contraceptive device and a collagen sponge. Native collagen fibrillar proteins are ground and homogenized in an acidic medium; what is not collagen is eliminated; the collagen is mixed with water, the pH of which is adjusted to 45-5.0 (CH 3 COOH); glutaraldehyde is added; the suspension is poured into molds which are frozen at about -10 degrees C for the time required. Thawed, washed and immersed in a bath (pH 8-9), to which sufficient reducing agent was added, for 2 hours at 20 degrees C. The sponge can then be immersed in a buffer solution (pH 4-5). /P P The sponge thus formed can be put in place by the user herself. This sponge may contain a bactericide and / or a slow release drug.