PROCESS FOR PREPARING 6-AMINOPENICILLANIC ACID BY ENZYMATIC TRANSFORMATION OF A PENICILLIN

摘要

The invention relates to a process for the preparation of 6-aminopenicillanic acid by enzymatic transformation of a penicillin. /P P Penicillins are deacylated to 6-amino-penicillanic acid by rapid recycling of an aqueous solution of penicillin through a shallow bed formed of particles containing immobilized penicillin acylase, at 15-45 degrees C and pH 6.5-9.0 until the air transformation reaches an appreciable rate. /P P 6-Aminopenicillanic acid is an intermediate compound in the preparation of synthetic penicillins.