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N-(Dichloroacetyl) diamine compounds and process of preparing same
N-(Dichloroacetyl) diamine compounds and process of preparing same
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机译:N-(二氯乙酰基)二胺化合物及其制备方法
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摘要
N-(Dichloroacetyl)-N'-(mono- or di-chlorobenzoyl)-1,8- octanediamines (I), acetaldehyde dehydrogenase inhibitors, indicating their usefulness as aids in treating alcoholism, are prepared by reacting a mono-acid- addition salt of 1,8-ocetanediamine with one molar equivalent quantity of a lower-alkyl dichloroacetate to produce N- (dichloroacetyl)-1,8- octanediamine and then reacting it with a mono- or di-chlorobenzoylating agent to produce I. Also shown is the process of reacting a mono-acid- addition salt of 1,6-hexanediamine with one molar equivalent quantity of a lower-alkyl dichloroacetate to produce N- (dichloroacetyl)-1,6- hexanediamine.
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