6*111DIHYDRODIBENZOOTHIEPINEE111ONE SSOXIDES* THEIR MANUFACTURE AND THEIR MEDICAL COMPOSITION* USE AND INTERMEDIATES USEFUL FOR THEIR PREPARATION

摘要

Novel 6, 11-dihydrodibenzo-[b.e.]-thiepin-11-one S-oxides, and intermediates useful in the preparation thereof, having the formulae CHEM wherein R is hydrogen, an alkyl group containing from 1 to twelve carbon atoms or a pharmaceutically acceptable salt thereof when R is hydrogen, R1 is hydrogen, chloro or methoxy, R2 is hydrogen or methyl, and R3 is chloro or methoxy. The free acid or ester of compound II, or its 8-R3 unsubstituted equivalent, can be converted to the corresponding compound I by oxidation. The compounds and compositions containing them can be used for treating inflammation or other conditions in mammals.