NOVEL 66OXIDATEDD3*200DIOXOOPREGNANE DERIVATIVES*THEIR MANUFACTURE AND MEDICAL COMPOSITION CONTAINING SAID COMPOUNDS

摘要

Disclosed are novel 6-oxygenated-3,20-dioxo-pregnane derivatives of the general formula I …CHEM… and specified 1,2-dihydroderivatives thereof. …CHEM… wherein Z represents specified acylgroups. …??The other substituents of formula I include those commonly met in known corticosteroids. …??The novel compounds may be prepared by methods known per se. The 6-acyloxy compounds of formula I are preferably prepared by subjecting a corresponding 6-oxo-compound of formula II, as herein defined, to esterification conditions. The 6-oxo-compounds of formula I are preferably prepared by oxidation of the corresponding 6-hydroxy-6,7-dihydro compounds. The novel compounds exhibit anti-inflammatory activity and are therefore useful in the treatment and control of inflammatory conditions.