Benzomorphanes as analgesics and morphine- - autogenists

摘要

Substituted 6,7-benzomorphanes of basic structure: in which the two Rs are lower alkyls or together and in combination with the ring carbon atom form a cycloalkane ring. The ring system may be substituted. Optically active form and salts are included. As examples are given e.g. methyl-2,2-dimethyl-4-(p-methoxyphenyl)-acetylacetate; methyl 3-benzylamino-2,2-dimethyl-4-phenyl-butyrate. The compounds are useful pharmaceuticals e.g. as analgesics and morphine-antagonists.