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Functionalized adenine derivatives for use in the preparation of macromolecular adenine derivatives.
Functionalized adenine derivatives for use in the preparation of macromolecular adenine derivatives.
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机译:用于制备大分子腺嘌呤衍生物的功能化腺嘌呤衍生物。
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摘要
Nicotinamide 6-(2-hydroxy-3-carboxy-propylamino) purine dinucleotide is prepared by reacting nicotinamide-adenine-dinucleotide with 3,4 epoxybutanoic acid in the presence of perchloric acid to prepare an intermediate wherein the adenine nucleus is alkylated in the N1 position. That intermediate is subjected to chemical reduction of the nicotinamide ring, followed by rearrangement to yield the end product wherein the amino group in position 6 of the adenine ring is alkylated.
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