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THE COMPOUND,4-CARBOXYPHTHALATO-(1,2-DIAMINOCYCLOHEXANE)PLATINUM(II)AND ALKALI METAL SALTS THEREOF AND ITS USE IN ALLEVIATING MURINE LEUKEMIA
THE COMPOUND,4-CARBOXYPHTHALATO-(1,2-DIAMINOCYCLOHEXANE)PLATINUM(II)AND ALKALI METAL SALTS THEREOF AND ITS USE IN ALLEVIATING MURINE LEUKEMIA
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机译:化合物4-羧基邻氨基-(1,2-二氨基环己烷)铂(II)和碱金属盐及其在消除白血病中的应用
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IMAGE IMAGE +TR IMAGE 4-Carboxyphthalato (1,2-diaminocyclohexane)platinum(II) (and alkali metal salts thereof) has shown antileukemic activity in mice against murine leukemia L1210. It is effective in dosages of 5-60 mg/kg of body weight and is potentiated in a treatment with cyclophosphamide (CY) (50 mg/kg of body weight) to which may be added 5-fluorouracil (5-FU) (75 mg/kg of body weight) or hydroxyurea (HU) (1000 mg/kg of body weight). Some previous platinum chelate compounds show dosage limitation due to renal impairment but the free carboxyl of the present Pt compound offers a possible route of oral administration and absorption by the stomach.
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