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NEW IMIDAZO-ISOKINOLIN-DIONER

机译:新的咪达唑-异KINOLIN-DIONER

摘要

Compounds of the formula IMAGE wherein R1 is lower alkyl; phenyl-lower alkyl; cycloalkyl of 3 to 6 carbon atoms; phenyl; mono- or di-substituted phenyl, where the substituents, which may be identical to or different from each other, are each halogen, hydroxyl, methoxy, methylmercapto, methylsulfinyl, methylsulfonyl or benzyloxy; and A is hydrogen or IMAGE where R2 is hydrogen or lower alkyl; R3 is lower alkyl or dimethoxyphenyl-lower alkyl; or R2 and R3, together with each other and the nitrogen atom to which they are attached, are piperidino, morpholino or N'-lower alkyl-piperazino; and n is 2 or 3; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, hypotensives, antithrombotics and antiarrhythmics.
机译:的化合物,其中R1是低级烷基;苯基-低级烷基; 3至6个碳原子的环烷基;苯基单或二取代的苯基,其中的取代基彼此相同或不同,分别为卤素,羟基,甲氧基,甲基巯基,甲基亚磺酰基,甲基磺酰基或苄氧基; A为氢或,其中R2为氢或低级烷基; R3是低级烷基或二甲氧基苯基-低级烷基; R 2和R 3以及彼此相连的氮原子是哌啶子基,吗啉代或N'-低级烷基-哌嗪子基; n为2或3;及其无毒的药理学上可接受的酸加成盐。该化合物及其盐可用作强心药,降压药,抗血栓药和抗心律不齐药。

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