ARYLSULFONYLCARBAMOYL-1,3-DICARBONYLALICYCLIC AND ARYLSULFONYLCARBAMOYL-1,3-DICARBONY-LACYCLIC COMPOUNDS

摘要

ARYLSULFONYLCARBAMOYL-1,3-DICARBONYLALICYCLICAND ARYLSULFONYLCARBAMOYL-1,3-DICARBONYL-ACYCLIC COMPOUNDSAbstract of the DisclosureA new class of arylsulfonylcarbamoyl-1,3-cyclohexanedionesand arylsulfonylcarbamoyl-1,3-dicarbonylacyclic compounds are disclosed.These substances have hypoglycemic or hyperglycemic properties andare of value in controlling abnormal blood sugar levels. The aryl-sulfonylcarbamoyl derivatives of 1,3-dicarbonylalicyclic and acycliccompounds are prepared by reacting an arylsulfonylisocyanate with a1,3-dicarbonylalicyclic or acyclic reactant. Typical embodimentsare 2-(N-p-chlorobenzenesulfonylcarbamoyl)-5,5-dimethylcyclohexane-1,3-dione and 5-(1-ethylpropyl)-2-(N-p-chlorobenzenesulfonylcarbamoyl)-1,3-cyclohexanedione.