method cardiac active 3beta - hydroxy - 14,15beta - oxy do 14beta - bufa - 4,20,22 - trienolidi, 3beta - (alpha - l - ramnopyranosidi): n va lmistamiseksi

摘要

1315235 Bufapolyenolides FARBWERKE HOECHST AG 19 April 1971 [8 April 1970] 26359/71 Heading C2U The novel compound 3#-(-L-rhamnopyranosyloxy) - 14,15# - epoxy - 14# - bufa - 4,20,22- trienolide is prepared from proscillaridin by successively acylating the three sugar hydroxy groups, dehydrating in the 14,15-position, adding hypohalous acid acoross the resulting #SP14/SP- double bond, dehydrohalogenating the resulting 14#-hydroxy-15-halo grouping, and lastly liberating the three sugar hydroxy groups by saponification. The novel compound is stated to be cardioactive and may be made up with carriers into pharmaceutical compositions for oral administration.