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Racemising 1-phenyl-2-aminopropanes - by oxidising to ketone with N-chloro succinimide then reaction with amine
Racemising 1-phenyl-2-aminopropanes - by oxidising to ketone with N-chloro succinimide then reaction with amine
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机译:外消旋的1-苯基-2-氨基丙烷-通过与N-氯琥珀酰亚胺氧化为酮,然后与胺反应
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摘要
Racemic cpds. of formula (I) Z = CF3O, CF3S, CF3,Cl or H, R1 and R2 are same or different H, 1-5C alkyl, 3-6C cycloalkyl, opt. chlorinated phenylalkyl or NR1-R2 is a heterocycle) is prepd. by (a) oxidising a particular optical antipode of (I) to ketone (II) by reaction with N-chlorosuccinimide at reflux in a polar solvent, treatment with alkali alkoxide then acidification, and (b) conversion of (II) to racemic (I) by reaction with HNR1R2. Process allows unwanted isomer of (I) to be racemised and hence increases yield of the desired isomer.
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