Antibacterial cephalosporin type cpds - eg 7-beta-(substd-acetamido)-3-(3-heterocyclyl prop-1-enyl)-ceph-3-em-4-carboxylic acids

摘要

Cpds. of formula (I) and their salts are novel: (where the propenyl double bond is trans; R1 is 1-methyl-tetrazol-5-yl or 1,2,4-triazoal-5-yl; R2 is H, Ph2CH, p-methoxybenzyl, p-nitrobenzyl, o-nitrobenzyl, benzyl, t.-Bu, 2,2,2-trichloroethyl, phenacyl or pivaloyloxymethyl; and R3 is thiophen-2-yl, CF3S, PhO, PhS, (1H)-tetrazol-1-yl or sydnone-3-yl). Cpds. are antibacterial agents with broad-spectrum activity useful as therapeutic agents and as antiseptic agents for cleaning and antiseptic compsns. Dose is 10-100 mg./kg. daily.