ADJUSTMENT OF BONE METABOLISM IN WARMMBLOODED ANIMAL AND DRUG FOR IT

摘要

PURPOSE:To adjust the bone metabolism in warm-blooded animals, by administering specific two types of dihydroxycholecalciferols. CONSTITUTION:Pharmacologically effective amounts of 1alpha,24-dihyroxycholecalciferol of formula I and 24,25-dihyroxycholecalciferol of formula II are administered to warm-blooded animals including men to adjust the bone metabolism thereof. Diseases associated with the decrease in the amount of bones induced by the bone metabolism disorder or the related diseases, e.g. rickets, renal osteodystrophy, osteoporosis, and Be et's diseases, can be treated or prevented. The bone culture test in a semisynthetic medium containing no serum of horses shows that the compound of formula I accelerates the calcium absorption by the intestinal tract, and that the compound of formulas I and II accelerate the ossification with the parathormone in vivo in the bone tissue.