The pyrido[2,3-d)pyrimidines are of the formula …CHEM… wherein R2 is hydrogen, hydroxy, alkyl, alkylthio, phenyl, 4-methoxyphenyl, 4-chlorophenyl, 1-pyrrolidinyl or methylphenylamino; R5 is hydroxy, alkylamino, 2-hydroxyethylamino, 2-alkoxymethylamino, dialkylamino, 4-methyl-1-piperazinyl, 4-morpholinyl or 1-pyrrolidinyl or amino with the provisos that if R8 is alkyl and R2 is phenyl then R5 is other than amino and if R8 is alkyl and R2 is alkylthio then R5 is other than 1-pyrrolidinyl; R is alkoxy, amino, monoor dialkylamino, 2-hydroxyethylamino, 2-alkoxymethylamino or 2-(dialkylamino)ethylamino; and R is hydrogen, alkyl, 2-alkoxyethyl, allyl, propargyl, phenyl, 4-methoxyphenyl, 4-chlorophenyl, benzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-(4-morpholinyl)-phenyl or piperonyl. The compounds are useful as anti-secretory agents. Some also exhibit antiallergy activity. Processes for preparing the compounds are described and also novel intermediates useful in the processes.
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