New Preparation method of 1 - (Piperonyl), (- naphthyl Methyl 2 - (3,4-dimethylphenyl), etilendioxibencil) -, (cumaranil - 5 - methyl - (benzoyl) and 5 (b) furanil - methyl) - 4 - (1,3,4 - thiadiazole - 2 - il) - Piperazines

摘要

Disubstituted piperazines of the formula: IMAGE wherein: IMAGE is naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, DELTA 3-chromenyl, thiochromanyl or DELTA 3-thiochromenyl, X is nitrogen and simultaneously Y is oxygen or sulfur, or X is sulfur, imino (NH) or methylimino (N CH3) and simultaneously Y is nitrogen, and R is hydrogen, lower alkyl, phenyl, halophenyl, lower-alkylphenyl or lower alkoxyphenyl. These compounds possess interesting pharmacological and therapeutic properties, and may be used as medicines, especially in the treatment of hypertension, peripheral vascular disorders and Parkinson's disease.