PHARMACEUTICAL COMPOSITIONS FOR PREVENTING GASTRO-INTESTINAL ULCERS COMPRISING QUINAZOLINONE DERIVATIVES AND A NON-STEROIDAL ANTI-INFLAMMATORY AGENT

摘要

1507804 Anti-inflammatory compositions SUMITOMO CHEMICAL CO Ltd 22 June 1976 [23 June 1975] 25956/76 Heading A5B Pharmaceutical compositions having anti - inflammatory activity for oral or rectal administration contain a non - steroidal antiinflammatory agent, a compound capable of inhibiting gastro - intestinal ulcer formation as a side effect of the oral or rectal administration of the non - steroidal anti - inflammatory agent and being a quinazolinone of the formula wherein R, is C 1-3 alkyl, cyclopropylmethyl or 2, 2, 2 - trifluoroethyl, R 2 is halogen, C 1-3 alkyl or C 1-3 alkoxy, and R 3 is phenyl or thienyl, or a non - toxic pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or diluent. The non - steroidal anti - inflammatory agent may be an indolylacetic acid e.g. indomethacin, 1 - cinnamoyl - 5 - methoxy - 2 - methyl - 3 - indolylacetic acid and 1 - (3, 4 - methylenedioxybenzoyl) - 5 - methoxy - 2 - methyl - 3 - indolylacetic acid; an anthranilic acid e.g. mefenamic acid and flufenamic acid or a pyrazole e.g. phenylbutazone. The compositions may be in the form of tablets, powders, dragees, sugar-coated tablets, capsules, suppositories, liquids, elixirs, emulsions, suspensions, syrups and waters.