imidazole benzodiazepines originals and their salts of addition with acid production process and application in quality of medicaments

摘要

Cpds. of formula (I) and their acid addition salts are new (where R1 is H, halogen, NO2 or CF3, R2 is H or halogen, R3 is H or CH3, R4 and R5 are each H, 1-5C alkyl, 1-5C hydroxy alkyl, amino-1-5C-alkyl, or 1-5C-alkylamino-1-5C-alkyl, aryl or cycloalkyl, or NR4R5 is a satd. heterocycle, opt. substd. and opt. contg. another heteroatom). Also new are inters. of formula (II) where R is H or lower alkyl except Et. (I) have sedative, hypnotic, anciolytic, tranquillising, anticonvulsant and myorelaxant activities, they are useful for treating agitation, irritability, agression, insomnia, certain psychosomatic syndromes, certain muscular contractions or spasms, certain character disorders, and certain behavioural disorders. Adult doses are e.g. 1-50 mg/day p.p. Admin. may be via the digestive tract or parenterally in conventional forms.