Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them

摘要

There are described compounds of formula I,;in which R₁ is phenyl substituted by halogen, alkoxy, alkyl, carboxy-alkyl, -NR₄R₅, carboxy or alkoxy carbonyl,;R₃ is hydrogen, alkyl, mono- or di-carboxy alkyl, halo, alkoxy, phenyl, halo-phenyl, hydroxy, phenoxy, thiol, thioalkoxy, thiophenoxy, -NR₄R_s, cyano, -COOH, carboxyureido, -CF₃, -CORe, hydroxyalkyl, aminoalkyl, or alkoxy substituted by NR₄R₅,;ring A is a benzene or a pyridine ring which optionally carries up to 4 substituents R₃, which may be the same or different,;R₄ and R_s, which may be the same or different, each represent hydrogen, phenyl, halophenyl or alkyl, the alkyl optionally being substituted by alkoxy or by a mono- or di- alkyl or unsubstituted amino group; or R₄ and R_s, together with the nitrogen atom to which they are attached, form a piperidine, morpholine or an optionally alkyl substitued piperazine ring, and;R₆ is hydrogen or alkyl,;provided that (i) when R, is phenyl substituted by chlorine or bromine, ring A is not a benzene ring substituted by chlorine or bromine, or (ii) when R, is phenyl substituted by methoxy R₃ is not phenyl,;and pharmaceutically acceptable salts, esters and amides thereof.;There are also described methods for making the compounds and pharmaceutical, e.g. anti-inflammatory, compositions containing the compounds.