Process for the preparation of the esters of N-acetyl-muramyl-L-alanyl-D-glutamic acid and of N-acetyl-muramyl-L-alanyl-D-isoglutamine

摘要

These compounds which correspond to the formula I where R1 = -NH2 or -OCnH2n+1 (n = 1, 2 or 3), R2 = -OCpH2p+1 and p = 0, 1, 2 or 3, p NOTEQUAL 0 when R1 = -NH2, are prepared by peptide linkage starting with the two amino acids or even the dipeptide L-Ala-D-Glu or L-Ala-D-iso-Gln. The compounds obtained are useful as anti-infectious agents or immune adjuvants. IMAGE