Substituted quinoxaline - 2 - carboxamide - 1,4 - dioxide

摘要

Compounds of the formulaPPWHEREIN X is a 6- or 7- position substituent selected from the group consisting of formyl, acetyl, hydroxymethyl, 1-hydroxyethyl and ##EQU1## wherein Y is selected from the group consisting of hydrogen and methyl; R.sub.1 is hydrogen or methyl; R.sub.2, when taken separately, is hydrogen or alkyl having 1 to 4 carbon atoms; R.sub.3, when taken separately, is hydrogen, alkyl having 1 to 4 carbon atoms, --(CH.sub.2).sub.n OH, --(CH.sub.2).sub.n OCH.sub.3, --(CH.sub.2).sub.n NH.sub.2, ##EQU2## or ##EQU3## wherein n is 2 or 3 and R.sub.2 and R.sub.3, when taken together with the nitrogen atom to which they are attached, form a member selected from the group consisting of pyrrolo, pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino, N-(lower alkyl)piperazino, N-hydroxy(lower alkyl)piperazino, N-(lower alkanoyl)piperazino and N-carbo(lower alkoxy)piperazino and the pharmaceutically acceptable acid addition salts of those compounds wherein R.sub.2 has an &ohgr;-aminoalkyl moiety; methods for their preparation; and their use as antibacterial agents and as agents for promoting growth and improving feed efficiency of animals.