首页> 外国专利> Substd. imidazolyl-thiazolyl-methane derivs. - are broad spectrum antimycotics esp. effective against dermatophytes, gemmiparous fungi and biphasic fungi

Substd. imidazolyl-thiazolyl-methane derivs. - are broad spectrum antimycotics esp. effective against dermatophytes, gemmiparous fungi and biphasic fungi

机译:取代。咪唑基-噻唑基-甲烷衍生物。 -是广谱抗真菌药,尤其是。对皮肤癣菌,双生真菌和双相真菌有效

摘要

Substd. imidazolylthiazolyl methane derivs. of formula (I) and their physiologically acceptable acid addition salts are new. In (I) R is opt. substd. Ph or furyl; R' and R2 are each H, alkyl or opt. substd. Ph or together with the thiazole ring form a benzthiazole gp.; X is alkyl, halogen, haloalkyl or Ph; m is 0 or 1; and n is 0, 1, 2, or 3. (I) have strong antimycotic properties. (I) have a very broad spectrum of activity and are esp. effective against dermatophytes and budding fungi as well as against biphasic fungi, e.g. against Candida, Epidermophyton, Aspergillus, Trichophyton, Microsporon and Penicillium. (I) can be used in human and veterinary medicine to treat dermatomycoses and systemmykoses. Suitable daily doses are 10-300 (pref. 50-200 mg/kg.
机译:取代。咪唑基噻唑基甲烷衍生。式(I)的化合物及其生理上可接受的酸加成盐是新的。在(I)中,R是优选的。取代Ph或呋喃基; R 1和R 2各自为H,烷基或opt。取代Ph或与噻唑环一起形成苯并噻唑gp。 X是烷基,卤素,卤代烷基或Ph; m为0或1; n为0、1、2或3。(I)具有强的抗霉菌性。 (I)具有非常广泛的活动范围,尤其是。对皮肤真菌和萌芽真菌以及双相真菌有效,例如对抗念珠菌,表皮癣,曲霉,毛癣菌,微孢子菌和青霉菌。 (I)可用于人类和兽医医学中,以治疗皮肤粘膜病和系统真菌病。合适的日剂量为10-300(优选50-200 mg / kg。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号