N-Acyl-N-substd.-sulphamoyl chloride derivs. prepn. - by reacting N-substd. sulphamoyl chloride with acyl halide in presence of base and washing with water

摘要

Prepn. of sulphamic acid chlorides of formula R1R2N-SO2-Cl (I) comprises reacting chlorides o formula R1-NH-SO2Cl (II) with halides o formula R2Y (III) in the presence of 1-1.5 equivs. of a basic cpd. per equiv. of (II) and in the presence of inert organic solvents, and treating the resulting reaction mixt. with the water at pH is not 7: In the formula, R1 is an aliphatic or cycloapliphatic residue; R2 is -Cs-R3, -CX-SR4, -CX-CX-XR4, -CX-CX-R3, -SCCl3, -SCCl2F, -P(X)(R5)2, -CH2-XR6, -SO-R3, -S-S-R3, -SO2-R3, propoxycarbonyl, or isopropoxycarbonyl; R3 and R4 are aliphatic, cyclicaliphatic, araliphatic, aromatic or heterocyclic residues and R3 can also be halogen; each R5 (same or different) is halogen, -XR6 or -R6; R6 is an aliphatic residue; each X (same or different) is O or S; and Y is halogen. (I) are useful as intermediates for plant protection agent, (esp. herbicides) dyes and pharmaceuticals. (I) are obtd. in high yields and purity without the formation of pollutant byproducts. The final aq. wash does not cause prod. hydrolysis. Some cpds. (I) are novel.