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Compsn. for absorbing diarrhoea-causing bacterial toxins - contg. ganglioside on a solid support, esp. for treating or preventing cholera
Compsn. for absorbing diarrhoea-causing bacterial toxins - contg. ganglioside on a solid support, esp. for treating or preventing cholera
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机译:Compsn。吸收引起腹泻的细菌毒素-续神经节苷脂在坚实的支持下,尤其是。用于治疗或预防霍乱
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Medicine consists of a ganglioside (I), or its deriv. attached to a support suitable for oral administration. (I) has affinity for toxin produced by diarrhoea-causing bacteria, esp. for cholera toxin. Supports include activated C; latex; opt. modified cellulose; or porous inorganic materials such as silica, alumina, TiO2, glass, silicates or kaolin, opt. covered by polysaccharides. (I) are pref. ganglioside GM1 (or its partial hydrolysis prods.), lysoganglioside GM1 or mono- or a -sialogangliosides formed by acid treatment. Pref. (I) are used at 1-20, esp. 3-10, mu moles per g. of support, and the materials are formulated with usual excipients to give final compsns. contg. 0.1-20, esp. 0.1-10 mu moles (I) per g. Compsns. are useful in treating or preventing acute diarrhoea, esp. cholera and that caused by E. coli. In this form (I) are insoluble and do not become attached to the intestinal cell walls, while the (I)-support bonding is stable towards acids and bile salts. The daily dose is 2-50 mu moles (I) for prevention, or 10-200 mu moles for curative use.
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