Method of production of a group of compounds butyrophenone 4 - oxo - 1 - phenyl - 1,3,8 - triazaspiro (4,5) decane, novel products thus obtained and their use as a antipsychotic activity, and analgesic

摘要

Butyrophenone compounds having excellent psychotropic activities represented by the formula: IMAGE wherein R1 is a halogen atom, R2 is a lower alkyl group, and Z is a group of either one of the formulae: IMAGE (1) (wherein the dotted line indicates the optional presence of an additional single bond linkage, R3 is a hydrogen atom or a hydroxyl group but only when said additional single bond linkage is not present and R4 is a hydrogen atom or a phenyl or benzyl group optionally substituted with one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy and trifluoromethyl on the benzene ring (except monohalophenyl)), IMAGE (2) (wherein the dotted line indicates the optional presence of an additional single bond linkage, R5 is a hydrogen atom or a lower alkyl group and R6 and R7 are each a hydrogen atom, a halogen atom or a lower alkyl group), IMAGE (3) (wherein R8 is a hydrogen atom or a lower alkyl group and R9 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group), IMAGE (4) (wherein R10 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group), or IMAGE (5)