A pharmaceutical compsn. consists of a cpd. of formula (I) which mimics the effect of gamma-aminobutyric acid, plus a neuroleptic (II) such as haloperidal or Chlorpromazine. In the formulae, X1-3 are each H, halo (esp. Cl or F), CH3 or CH3O. n=1-10. R=OH, OM, NH2, NH(CH2)3COOH, NH(CH2)3COOM, NH(CH2)3 COOC2H5,NHR1 or NR2R3. M=alkali metal, esp. Na. R1=3-6 C cycloalkyl, phenyl, benzyl (opt. substd. by =1 halo or (F3), or 1-4C alkyl. R2=1-4C alkyl. R3=1-4C alkyl or benzyl. Excluded is the cpd. with X1=X3=H; X2=5-chloro; n=1 and R=OH. Used in psychiatry, esp. for treating psychoses such as schizophrenia (I) potentiates catalepsis induced by (II), so the amt. of (II) used is reduced. The compsns. are administered to humans or animals orally, enterally or parenterally at a daily dose of e.g. 50-500 mg chlorpromazine and 0.1-1g (I).
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机译：制药公司。由cpd组成。模仿γ-氨基丁酸作用的式（I）的化合物，加上抗精神病药（II）例如氟哌啶或氯丙嗪的化合物。式中，X 1-3分别为H，卤素（尤其是Cl或F），CH 3或CH 3O。 n = 1-10。 R ＝ OH，OM，NH 2，NH（CH 2）3 COOH，NH（CH 2）3 COOM，NH（CH 2）3 COOC 2 H 5，NHR 1或NR 2 R 3。 M ＝碱金属，尤其是。娜。 R 1 ＝ 3-6个C的环烷基，苯基，苄基（优选被≥1个卤素或（F 3）取代，或1-4 C烷基。R2 ＝ 1-4 C烷基。R3 ＝ 1-4 C烷基或苄基。 cpd。X1 = X3 = H; X2 = 5-chloro; n = 1和R = OH。用于精神病学，尤其是用于治疗精神分裂症等精神病（I）增强由（II）引起的回弹，因此amt将组合物以例如50-500mg氯丙嗪和0.1-1g（I）的日剂量经口服，肠内或肠胃外施用于人或动物。
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