Novel bicyclic compounds having the fundamental frequency of the skeleton 5 - methylene - 2 - 1.1 - 7,9 - diazabicyclo (4,2,2) decane, their preparation and their application as medicinal products

摘要

Case 4-10641/+ Canada Bicyclomycin derivatives (i.e. compounds with the skeleton of the 5-methylene-2-oxa-7,9-diazabicyclo¢4,2,2!decane) of the formula (I) wherein Ra to Rd represent hydrogen atoms or hydroxyl protective groups, X represents a free or functionally modified carboxyl group, a substituted or unsubstituted hydrocarbon radical or a halogen atom, and n is 0 or 1, possess valuable antibiotic properties which are of importance in particular for combating infections caused by Enterobacteriaceae and Proteus species.