Compsns. for cerebral and peripheral vascular disorders - contg. di:hydro-ergocristine papaverine and aescin

摘要

Compositions having an action on the cerebral and peripheral vascular system contain dihydroergocristine (I) or one of its salts, papaverine (II) or one of its salts, and aescine (III) or one of its metal salts. Each unit dosage contains 0.5-2 mg (I), 20-150 mg (II), and 5-30 mg (iii). The compositions may be formulated for oral, parenteral, sublingual, percutaneous or rectal administration. LD50 in mice, po=2213 mg/kg. That of (I) alone is 350 mg/kg, (II, HCl) alone is 1085 mg/kg and (III) alone is 422 mg/kg. Used in treatment of e.g. atherosclerosis and geriatric cerebral disorders, disorders caused by arterial hypertension, thrombo-embolic disorders, circulatory disorders, venous insufficiency and varicose syndromes.