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Prepn. of i-phenyl cyclopentane carboxylic acid - by reaction of phenyl acetonitrile with a butane di:halide, followed by hydrolysis
Prepn. of i-phenyl cyclopentane carboxylic acid - by reaction of phenyl acetonitrile with a butane di:halide, followed by hydrolysis
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机译:准备苯基环戊烷羧酸的合成方法-苯基乙腈与二卤化丁烷反应,然后水解
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摘要
1-Phenyl cyclopentane carboxylic acid (I) is prepd. by the alkylation of phenylacetonitrile (II) with a dihalide X(CH2)4X (III) (where X = halogen) in aq. NaOH and DMSO and the prod., 1-phenyl cyclopentane carbonitrile is hydrolysed to (I) is an acid medium at =120 degrees C. Esters of (I) with aminoalcohols are antispasmodics and antitussives. The process is simple and economical to carry out, and gives good yields. The molar ratio (II):(III) is preferably 1:1, 1,4-dibromo butane being the pref. dihalide (III). The sodium hydroxide soln. usually contains 300-500g per kg and the weight ratio of (II) : DMSO is generally within the range 1 : 1 to 1 : 2.
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